As we discussed in the main text, expression levels of genes in the same CNV segments are likely to be correlated so that they are assigned into the group.
The main difficulty in inferring expression levels for full-length isoforms lies in the fact that current sequencing technologies generate short reads (from few tens to hundreds of bases), many of which cannot be unambiguously assigned to individual isoforms.
This unexpected result may be derived from multiple functions of ANXA1, which can be the main causes of different expression levels and roles of ANXA1 in different types of cancers.
Gene levels of MMP-9, a collagen-degrading enzyme, were not modified in response to AngII treatment, while aortic TIMP-1 expression levels, the main inhibitor of MMP-9 [17], were upregulated (Figure 4A).
To test the relevance of some markers selected by cross-validation between the two main datasets, we measured the expression levels of six differential genes, CASP10, CDH16, CLGN, CRABP1, HMGB2 and ALPL2, on 32 new follicular tumor samples, including eight samples each of FTA, FTAb, OTA and FTC (Figure 4A).
The first component (PC1) separates two samples of one genotype from two samples of the other genotype, indicating genotype is the main factor that determines miRNA expression levels.
The first analysis looked for a main effect of state, comparing expression levels between all sleep-deprived (awake) and sleeping (sleep) animals.
Another study, performed in an African-American population, with baseline and postdexamethasone suppression cortisol levels and microarray-assessed gene expression levels as main outcome measures, showed that functional variants of FKBP5 polymorphisms are associated with biologically distinct subtypes of PTSD.
Increased adipogenesis was associated with an increase in mRNA expression levels of main adipogenesis transcription factors, Pparγ and Cebpα Tgm2−/− MEFs showing a 1.8-fold and 1.5-fold increase, respectively, compared with Tgm2+/+ MEFs on day 8.
CaHsfA1d, A2, A3, A6c, B1 and B5 were the main members with significantly higher expression levels during HS in B6 and R9 leaves (Fig. 4), which suggested that these CaHsfs were major transcription factors of heat-induced Hsp genes under HS conditions [ 41].
