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The study population was first characterised regarding sociodemographics (age, nationality, occupational group), main exposures, and covariables potentially associated with both exposures and serum γ-GT.
Even within this sample, however, the main exposures and outcome were similar to those of other populations.
Univariate analyses were conducted to evaluate the unadjusted associations between enrollment, the main exposures, and all covariates.
We have adjusted the regression models for these maternal lifestyle factors, as they are known to be related with the main exposures and outcomes.
The measurement of our main exposures and covariates clearly preceded that of our alcohol use outcomes, thus minimizing the possibility of reverse causation or recall bias.
In the PS-adjusted models, the estimated effects of both main exposures, and of their interaction, were very similar to the estimates from our multivariable model (see Additional file 1).
Similar(49)
Of note, results of models 1 3 in Table 1 (25(OH D as the main exposure) and Table 3 (adjusted calcium as the main exposure, N = 3,958) were not different from those presented when the sample was restricted to participants with PTH measures (N = 2,554).
Models were run for each main exposure including an interaction term between the main exposure and sex.
Cohort studies which performed only cross-sectional analysis between main exposure and outcomes were also excluded.
Key success factors for collaborative analyses are common definitions of main exposure and health variables.
The studied exposures include donor age as the main exposure, and donor sex, donor recipient compatibility and blood type as secondary exposures.
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