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Exact(7)
In general researchers will ignore a non-significant two-way interaction and interpret the two main effects which are considered to be independent of each other.
Here, by specifically examining those single-SNPs which had main effects which did not replicate for pairwise interactions the multiple testing burden is further reduced.
For example, in the absence of main effects (which is not the same as assuming no marginal effect and plausibly consistent with modest marginal genetic or environmental effects), the BPC3 has 89% power to detect an interaction effect of 1.2 assuming an allele frequency of 20% and an environmental exposure with a prevalence of 20%.
These columns represent the main effects, which indicate for each array whether the yeast was grown under the relevant setting of a particular cultivation parameter.
These columns represent the main effects, which indicate, for each array, under which category of a particular cultivation parameter type, the yeast was grown.
One cannot invoke insufficient statistical power as being responsible for the non-significant interaction, because the interaction term has more degrees of freedom than the two main effects, which are both highly significant.
Similar(53)
ORS2 concluded that the success of Charnwood owed little to the bombing and made recommendations including changing to instantly fused bombs, dropping larger numbers of smaller anti-personnel bombs and rapidly following-up a bombardment with ground forces to take advantage of its main effect, which was the temporary suppression of German will to resist.
It is likely that Arana et al. [18] essentially obtained the same result in their study, but because they did not manipulate hunger, they interpreted the difference as a main effect, which truly was masking an interaction.
Their destructive impact persists in the statistical model as the ablation main effect, which subtracts across age groups from constructive development normally represented by the age main effect.
This is an example of epistasis with no main effect, which may indicate the epistatic alleles have a negative effect on their interaction partner.
Furthermore, we performed a subtraction analysis of the main effect, which showed significant differences and both common and respective activation in the four experimental conditions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com