In the phase 1 setting, partial response to KPT-335 was observed in dogs with NHL, and unlike previously tested XPO1 inhibitors such as leptomycin B [ 55], KPT-335 exhibited good tolerability with anorexia and weight loss as the main clinical effects noted [ 33].
No main effects were noted for gender except that heart rate was significantly lower in boys.
For outcome assessed 6 months after aSAH, no significant main effects were noted for time (F (4.68, 154.4) =.948; p =.448) or interaction of time and outcome after 6 months (F (4.68, 154.4) =.878; p =.492).
A significant main effect was noted in medication intensity for nurse gender (F [1,384] = 9.75, p = .002).002
The main effect of Note and the Time × Note interaction were trending toward significance (F 4, 10) = 2.327, p = 0.073, F 4, 10) = 2.015, p = 0.111, respectively), likely reflective of the small sample size.
Given the low-pass nature of brainstem phase-locking [39], [40] and the fact that Notes 3 and 4 are higher in pitch than Notes 1 and 2, the main effect of Note was expected for both H2 and F0.
An ANOVA for a time window ranging from −150 to −80 ms (i.e., before note onset) with factors Keypress and AntPos indicated a significant main effect of Note (F 1,9) = 8.3, p = .018), but no interaction between Keypress and AntPos (F<1).
While this is thought to be the main effect, da Silva Filho also noted that this appliance also rotated the mandible down and back together with distalization of the mandibular teeth and mesialization of the maxillary teeth [13 16].
Finally, we would also like to note that possible main effects of language were confounded by the fact that the English experiment was conducted at NYU Abu Dhabi and the ASL experiment at NYU New York.
