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The analysis with correction for main effects leads to the detection of two-locus effects beyond co-dominant main effects.
The analysis without correction for main effects leads to the detection of a two-locus model but without giving a clue about whether this model is genuinely indicative for epistasis or for main effects, or for both.
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We then assessed the interactive relationship between lead and stress by testing a model that included the main effects of lead and stress plus an interaction term of lead times stress to predict MMSE score.
An important implication of these examples for risk assessment is that the "main effects" of lead or PCBs or ETS, estimated by multiple regression, are misleading characterizations of their respective associations with neurodevelopment.
A pot experiment employing factorial design with two main effects of fertilizer and lead was conducted in a nursery using sand tailings from an ex-tin mine as the growing medium.
PGMDR without main effects correction does not lead to a significant interaction.
An examination of simple main effects revealed that smiling emoticons led to higher ratings of healthiness than frowning emoticons, but only when the colour label was white, F 2, 937) = 6.74, p = .001, η = 0.014, and not when the colour label was green or red, Fs < .98, ps ≥ 0.376.
In the priming experiment, synaesthesia was elicited in the CC and IC conditions, and not in the NC condition: we therefore investigated whether the CC and IC conditions would lead to similar main effects of synaesthesia as those that were found in Experiment 1.
While CART is well suited for identifying important main effects and interactions, it does not lead to quantitatively meaningful effect estimates.
Misclassification of exposure generally leads to attenuation of the main effects when the error is non-differential [ 51].
We also ran regression models including a cross-product term for interaction between each genotype and each lead marker along with the main effects.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com