Sentence examples for main effector pathways from inspiring English sources

To directly discriminate between the two main effector pathways involved in this effect, the same experiment was performed with active PI3K or Raf pathway mutants.

Four main effector pathways of the IFN-mediated antiviral response have been recognized by gene targeting studies: the Mx GTPase pathway, the 2', 5'-oligoadenylate-synthetase-directed ribonuclease L (OASL) pathway, the protein kinase R (PKR) pathway and the interferon stimulated gene (ISG) 15 ubiquitin-like pathway.

RAF-MEK-ERK and PI3K-AKT are the two main effector pathways of KRAS.

The hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic nervous system constitute the main effector pathways of the stress system.

CD11b+Gr-1+ cells inhibit antigen-activated T cells through a cognate-independent mechanism that involves arginase and nitric oxide synthase as the main effector pathways [ 60].

Below, we will discuss the main effector pathways of KRAS and current approaches to develop combination therapies targeting these KRAS-effector pathways.

This cascade is a main effector pathway of ERBB receptors, and altered in a high percentage of cancers usually be mutation of Ras or BRAFgenes.

This seeming contradictory function of cyclic AMP as both a mitogen and in promoting differentiation has been suggested to result from the two main downstream effector pathways of cyclic AMP, PKA and the exchange protein activated by cyclic AMP (EPAC) [ 46].

Lef1 represents another main effector of this pathway in HF morphogenesis; indeed, Lef1- null mice lack hair coat, and transgenic mice overexpressing inactive forms of Lef1 present severe alteration of differentiation and HF cell fate.

Protein kinase B (PKB) is the main effector of the PI3K pathway.

On the other hand, dTIEG also regulates the expression of STAT92E, the main effector of the JAK/STAT pathway.