Sentence examples for main effector genes from inspiring English sources

Our experimental protocol includes the use of LIF-starved ES medium, so the receptor (Gp130) and main effector genes (Erk1/2 and Stat3) of the LIF pathway were analysed.

As suggested in a recent work, there is a lack of mouse models where the functionality of main effector genes of the PI3K cascade is altered by the manipulation of their regulators [ 47].

Combinatorial analysis showed that E6 is the main viral effector gene.

Combinatorial ectopic expression of the two HPV oncogenes (E6 and E7) in an HPV- HNSCC cell line partially phenocopied the hypermethylation signature seen in HPV+ HNSCC tumors, and established E6 as the main viral effector gene.

Among the genes related to apoptosis, we noted that the genes encoding caspases, the main effector molecules in ovarian apoptosis, were only modestly expressed in the infant ovary and their expression increased in variable degrees in the adult ovary.

Four main effector pathways of the IFN-mediated antiviral response have been recognized by gene targeting studies: the Mx GTPase pathway, the 2', 5'-oligoadenylate-synthetase-directed ribonuclease L (OASL) pathway, the protein kinase R (PKR) pathway and the interferon stimulated gene (ISG) 15 ubiquitin-like pathway.

While recognizing that Tcf3 also regulates other key genes in the pluripotency circuitry, these findings pinpoint Esrrb as the main effector through which the Gsk3/β-catenin/Tcf3 axis modulates ESC self-renewal.

The main effector in glucose repression is Mig1, a zinc finger protein that binds to the promoters of many genes and represses their transcription [ 14- 18].

Analogously, one may speculate that Piwi-like proteins, as the main effector component of the RNA-induced silencing complex (RISC), may regulate their own expression by post-transcriptional gene silencing via an unknown small RNA binding partner.

We also find that enzymes that act as effector genes for the production of endogenous effector metabolites are more conserved than their corresponding effector genes encoding for transport and two-component systems for sensing exogenous signals.

To this end, the ectopic expression of transgenes (effector genes) offers great engineering potential.