Sentence examples for main effector enzymes from inspiring English sources

The requirement of caspases as the main effector enzymes in the initiation of the apoptotic cascade is still a matter of debate (Krammer, 1998; Pinkoski et al, 2000).

Caspases are known as main effector enzymes responsible for the initiation of DNA-fragmentation and the typical morphological changes in apoptosis (Henkart, 1994; Krammer, 1998).

A development allowing more automation and larger sample sizes might be the detection of activated caspase-3, the main effector caspase in the apoptotic enzyme cascade, by using fluorogenic substrates and detection of enzyme activation in microplate readers [ 30].

This was unexpected as HIF-1 upregulates transcription of most glycolytic enzymes and is generally regarded as the main effector of the Warburg effect - i.e. the enhanced glycolytic flux observed in cancers.

We demonstrated no significant difference between the enzyme activity of the initiator caspases -2, -8, -9 and the main effector caspase -3 in cells treated or not treated, suggesting that apoptosis in these cells may be caspase-independent (Additional file 1: Figure S1).

In summary, because of the potency of RASFs in producing cartilage-degrading and bone-degrading enzymes and their stimulatory effect on osteoclasts, RASFs must be regarded as the main effector cells for the activation and stimulation of osteoclasts, which leads to the primary problem in RA: joint destruction.

The main effector of this system is angiotensin II (Ang-II), which derives from the proteolytic cleavage of angiotensin I (Ang-I) by angiotensin converting enzyme (ACE).

However, there are still many challenges remained to investigate these effector enzymes, lipid kinase.

Consequently, we hypothesized that trypanosome PTKs might be effector enzymes for DAG signaling.

However, it is unlikely that CCR7 is the main effector of TLX1-induced oncogenesis.

Protein kinase B (PKB) is the main effector of the PI3K pathway.