Sentence examples for main effector caspase from inspiring English sources

Caspase 3 is the main effector caspase that is involved in both external and internal apoptosis pathway and it is the most abundant caspase in the brain [22].

Caspase-3 has been recognized as a main effector caspase in the apoptotic cascade.

Activated caspase-3 is generally considered the main effector caspase during the execution phase of apoptotic cell death (Koester and Bolton, 1999; Herngartner, 2000; Vaux, 2002).

Although Drice and Dcp-1 are highly similar in sequence, several studies have shown that Drice and not Dcp-1 is the main effector caspase in Drosophila [ 41, 43].

As the Hsp70 isoforms are known to play important anti-apoptotic roles, we next studied the effect of Hsp72 and Hsc70 knockdown on Caspase-3 cleavage, the main effector caspase involved in both the intrinsic and extrinsic apoptotic pathways.

One should note that Bax, the positive control, was less toxic in MCF7 cells than were the interface mutants due to the lack of endogenous caspase-3, the main effector caspase.

However, the main effector caspase-3 appeared as largely arrested at a premature 20-kDa cleavage product; and caspase-9 was not cleaved.

AIF is a main effector in the caspase-independent necroptotic process induced by the treatment of MEFs with high doses of the nitrosourea MNNG.

Survivin is an inhibitor of apoptosis and acts upstream of the main effector proteases of apoptosis, caspase 3 and 7, and is active in a cell-cycle regulated manner during the G2/S phase, as a safeguard against activated cell death during successive rounds of cell division.

Among the genes related to apoptosis, we noted that the genes encoding caspases, the main effector molecules in ovarian apoptosis, were only modestly expressed in the infant ovary and their expression increased in variable degrees in the adult ovary.

Interestingly, STS induced a significant activation of caspase-8, the main effector of the extrinsic pathway in apoptosis.