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We attribute this main effect to the difficulty of perceiving and localising several simultaneous touches.
Replicate was treated as a main effect to estimate its impact on transcript variance within this specific experiment.
If that were the case we should expect all combinations involving the gene/SNP with the strong main effect to yield a high signal.
In the subsequent replication phase it is possible for that main effect to be confirmed (Figure 3B), no effect to be detected (Figure 3C), or a main effect in the opposite direction may be detected (Figure 3D).
In our study, the main effect to RA risk came from HLA-DRB1*04 allele.
Nevertheless, the reported statistics given in the Tables were adjusted for the gender main effect to obtain unbiased information.
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The research shows that: Construction of Huitengxile wind farm has three main effects to ecological environment of the region.
We identified and validated three independent effects to MHC class I genes, with main effects to the imputed four-digit allele HLA-C*0602 HLA-C*0602d aminosition 67 of HLacidatd HLA-A*0201.
Gene-gene interactions (i.e., deviation from a multiplicative model) were tested by comparing a logistic regression model including only the main effects to another model including the main effects and an interaction term with a likelihood ratio test.
Additionally, for the models in this study, conditioning on main effects to detect epistasis would fail, and previous simulation studies have shown this is less powerful than exhaustive searches, even when the interaction models contain main effects [18].
Filtering by main effects to create a subset of SNPs on which all possible interactions are tested for, fails to capture high significance pairs with low main effects.
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