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The power of the main effect test for treatment was examined.
Significant interactions with treatment were analyzed with simple main effect test followed by Fisher LSD where indicated.
SNPs in the MRPS30 region of chromosome 5p12 have a higher ranking overall with the combined versus the main effect test.
If an interaction between 2 factors in a group at 1 time point was significant in the repeated MANOVA, a simple main effect test of the group difference at the same time point was applied.
The main effect test statistic is asymptotically independent of each of the case-only test statistics [ 23], and the interaction tests for E-alone and E+P are independent since they are based on non-overlapping sets of women.
Because a significant interaction between treatment assignment and initial weight loss was found, a major assumption underlying the main effect test of treatment effect in the primary analysis model was not met, and the test on the main effect term is interpreted with caution.
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Empirical results show that the presence of epistasis can increase power to detect the underlying loci compared to the non-epistatic additive case, in two-marker full model tests as well as in single-marker main effect tests.
A GLMM model was used as before but the main effect tested was location (IA-I versus IA-II).
In case of significant interactions, simple main effect tests were performed; that is, the effects of one factor holding the level of the other factors fixed.
Simple main effect tests showed that rats in the Adol HF groups were significantly heavier than rats in the Adol LF groups (p <.001) in Phase 1.
The test statistics for differential correlation on the off-diagonal tended to be larger than the test statistics for the main effect tests on the diagonal in these simulations, even in the absence of differential correlation.
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