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SNP-dietary factor interaction analyses were performed by including the corresponding interaction term as well as the complementary dietary main effect term in the model.
The model included a main effect term for bone lead as well as an interaction term between bone lead tertiles and number of years between ECG measurements.
We rescaled age (age minus 12) so the main effect term of age could be meaningfully interpreted in the model that included interactions with age.
For each independent variable, effects were estimated by both a main effect term (effect on initial fertility at the birth of the study child) and an interaction term with time (effect on rate of fertility change per year).
Because the current version of MTP in R can only include one term that varied across models, our team modified it to include two terms, i.e., the main effect term of genes and the interaction term of one pollutant and genes.
Because a significant interaction between treatment assignment and initial weight loss was found, a major assumption underlying the main effect test of treatment effect in the primary analysis model was not met, and the test on the main effect term is interpreted with caution.
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The main effect terms are denoted by the number of gears in table (1st gear, 2nd gear, 3rd gear, 4th gear, 5th gear and differential gear assumes as a covariate).
Likewise, maternal gene variant main effect terms were not significant.
After identifying optimal main effect terms, we evaluated potential interactions through a model-based recursive partitioning algorithm testing candidate main effect terms for joint significance.
The main effect terms were centered before the interaction term was computed.
Each of the terms enriched among treatment main effect genes was included in the enriched time main effect terms.
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