The main effect outcomes are Qol, challenging behaviors, staff attitudes toward dementia, job satisfaction and burnout of caregivers.
All reported results concerning the effects of sleep complaints on clinical outcomes (main effects and interactions) remained significant also in additional analyses controlling for the baseline values of the outcomes.
One possible explanation of this effect is that previous studies were focused on identifying genes with large main effects associated with clinical outcomes.
The presence of effect modification by sex and race/ethnicity (i.e., white vs. nonwhite) was explored using multiplicative interaction terms for the PFCs with evidence of main effects on the asthma outcomes.
It is noteworthy that, with the exception of behavioural expectations, there were no significant main effects of self-affirmation on outcomes.
Baby having trouble sleeping remained associated in the final main effects parsimonious model for both outcomes - EPDS >9 (OR 1.15; 95% CI: 1.06 – 1.25) and EPDS >12 (OR 1.16; 95% CI: 1.04 – 1.04).
For determining the effectiveness of NET vs. waiting list, with α = 0.05, d = 0.85 (f ≈ 0.40) and a priori test power = 0.80 (β = 0.20), 52 participants would be required for analyses of covariance of fixed effects, main effects and interactions on primary outcomes.
We used analysis of variance (ANOVA) to detect main effects and interactions on continuous outcomes—Univariate ANOVA was used for the LEIDS-R and neuroticism total scores and a separate multivariate ANOVA for the LEIDS-R subscales, because of high correlations with the total score.
Biologic variables were predicted from variables entered in three steps: a) potential confounders including medical variables (asthma severity classification, use of inhaled corticosteroids, use of beta agonists) and any demographic variable associated with study outcomes; b) main effects of chronic stress and air pollution; and c) the interaction term for chronic stress by air pollution.
Outcomes will be analysed using general linear models for each of the change outcomes, including the main effects of group and time and the interaction of group and time.
