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Main effect estimates were not appreciably altered by inclusion or exclusion of a range of covariates or adjustment for baseline CIMT, and adjusted coefficients were without exception slightly larger than the crude associations.
Among regions, main effect estimates were significant for Gipuzkoa only [β (95% CI) = –5.15 (–8.04, –2.27) and –5.49 (–9.21.761.76), respectively, for a doubling of each compound].
Smoking and illicit drug use were not included in the model because few women reported these behaviors and they did not influence main effect estimates.
The precision of the main effect estimates was similar for the models adjusted for CDS-ID only and age only (95% CI width 4.87 and 4.71, respectively).
In that case, because the effect estimate is subject to the winner's curse only in the first group, the apparent difference in the main effect estimates between the two groups could be misinterpreted as evidence for interaction.
In addition, birth weight, gestational age, breast-feeding, and lead did not confound associations between DAPs and attention or ADHD, because these factors did not change the main effect estimates by > 10% when added to or removed from models.
Similar(42)
In addition, we performed a meta-analysis using the main effect estimate from each of the 26 epidemiological studies.
The direct effects of both measures of SEP were modelled in logistic regression; odds ratio was the main effect estimate.
Covariates were selected in the regression procedure if they changed the R and/or main effect estimate by > 10%.
The direct effects of both measures of SEP on binary outcomes was modelled in logistic regression and odds ratio was the main effect estimate.
Accordingly, the main effect estimate for any locus was taken to be the difference between the effect of the Dd2 genotype and the HB3 genotype.
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