The Mod-Pb group learned significantly more slowly than controls (main effect contrast, p = 0.004).
The overall activity levels reduced with contrast (P < 0.001, three-factor anova, main effect contrast).
Chelation offered a significant benefit in that the Mod-Pb succimer group learned significantly faster than the Mod-Pb succimerain effect contrast, p = 0.03) and did not differ from controls for any session.
The right and left M1 were defined in each individual by the local maximum of the SPM{ t}, which was highlighted by the main effect contrast for each hand movement across all frequencies.
To plot the amplitude of the brain activity in M1, we calculated the beta value for each frequency, and the hand conditions in the right M1 and the left M1, where the contralateral local maximum was defined by the main effect contrast for each hand.
The factorial design enabled us to assess the following 6 main effect contrasts: Body > Nonbody, Nonbody > Body, Long SOA > Short SOA, Short SOA > Long SOA, fluent apparent motion > nonfluent apparent motion, and nonfluent apparent motion > fluent apparent motion.
These figures were analysed in an ANOVA with factors Contrast (Same-Function or Cross-Function) and Group (control or ASD), revealing a significant main effect of Contrast [ F 1,30) = 20, P = 0.0001] and, importantly, a Contrast × Group interaction [ F 1,30) = 10, P = 0.003].
No main effect of contrast was found, although there was an interaction between layout and contrast in reaction time for hits.
Split-plot ANOVA revealed a highly significant main effect of contrast (F2,52 = 37.19; p < .0001) and interaction between group and contrast (F2,52 = 8.07; p < .001); the main effect of group was not significant (F1,26 = 0.22; p = .64).64
LMM analyses revealed a significant three-way interaction between group, contrast and time, F 3, 113) = 6.06, p = .001, and a main effect of contrast, F 1, 112) = 168.10, p < .001.001
The results of the split-plot ANCOVA revealed a significant main effect of contrast (F2,50 = 71.93; p < .001), and a significant three-way group x adaptation x contrast interaction (F2,50 = 9.06; p < .001).001
