Sentence examples for main effect association from inspiring English sources

The latter allows our analysis to provide powerful null evidence against a main effect association between breast cancer risk and variants in these genes that are common among Caucasian women as well as in defined subgroups of the study population.

Table 1 also shows P-values and rankings for these SNPs under the main effect association test alone.

Each factor was added to the race-adjusted model to determine whether its inclusion changed the magnitude of the main effect association.

The model with the interaction term suggests that this overall relationship is characterized by a strongly positive main effect association (β = 0.50) and negative interaction term coefficient (β = -0.11).

Noting that there was no main effect association of rs2544390 with serum urate in either European or Māori and Pacific Island control sample sets (Table  2), it is possible that the rs2544390 association with gout and the alcohol-genotype interaction influencing gout risk in Polynesians is by a mechanism separate to the control of serum urate.

This algorithm operates on a network, encoded as a weighted matrix, A, with diagonal terms that correspond to the main effect association of the gene on the phenotype and off-diagonal terms that correspond to the interaction effect on the phenotype or differential co-expression.

Table 3 reports results with ptrend≤0.05 for the main effect associations between each SNP and lung cancer risk overall and by histology.

The intensive SNP tagging approach used provided a close to exhaustive analysis of possible mono-allelic (main effect) associations of prostate cancer risk with common polymorphic variants known for each of the loci studied.

We then compared these GxE SNPs to SNPs supporting main effect associations to cardiometabolic phenotypes in two important resources.

However, the contribution to phenotype variance that could be explained solely by main effect associations for many cardiometabolic traits was quite small [ 44].

In order to compare GxE SNPs to SNPs supporting main effect associations, we first compiled a list of SNPs in high LD with the lead GxE SNP.