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The main effect analyses partly confirmed our hypothesis: there was a main effect of Melody in the PMD; the pre-SMA was present in the main effect of Rhythm, as predicted, as well as in the main effect of Melody.
To address the primary research questions in the present study, we followed our main effect analyses with moderator analyses, examining interactions between birth cohort and family socioeconomics as predictors of selection into ECEC at 18 months.
For behavioral and main effect analyses see Supplementary Data.
The same allele was also associated with sensitization in the main effect analyses in our study.
Moderator analyses were conducted to examine the conditions under which moderating variables interacted with the intervention condition as predictor variables in the main effect analyses.
Though, bedroom PM2.5 concentrations were not associated with COPD outcomes in main effect analyses previously published [ 4], we found statistically significant interactions between bedroom PM2.5 and atopy for both nocturnal respiratory symptoms and risk for severe exacerbations.
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As there was no heterogeneity in results across cohorts for any main effects analyses, we only reported results from pooled analyses across all cohorts combined.
The results of the main effects analyses were internally validated using the bootstrap resampling method [ 19].
Main effects analyses have explained little of the genetic heritability of obesity.
Further post hoc Bonferroni tests or simple main effects analyses were conducted to explore any significant main effects or interactions resulting from the anovas.
For both outcomes, only the results of the main effects analyses are reported as both interactions were not significant and their inclusion did not significantly improve model fit.
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