Sentence examples for main downstream mediator from inspiring English sources

Consequently, the main downstream mediator of these pathways, p53, was phosphorylated on its Ser15 (Ser18 in rodents), which was associated with an overexpression of p21Cip1 and p16INK4A.

p70S6K (p70 S6 ribosomal protein kinase) is a main downstream mediator of mTOR and phosphorylation level of p70S6K at Thr389 could be used as a probe for mTOR activity.

Two main downstream mediators of cAMP are protein kinase A (PKA) and exchange protein directly activated by cAMP (Epac).

p53 deficiency can rescue both survival and tumorigenesis in Terc −/− p53 −/− mice, indicating that p53 is one of the main downstream mediators of the cellular response to DDR triggered by short telomeres (Artandi et al., 2000).

In addition, PI3K/Akt/mTOR (downstream mediator of EGFR signaling) may function as a compensatory EGFR signaling pathway; mutations in the main catalytic subunit of PI3K (PIK3CA) have been associated with primary and acquired EGFR-TKI resistance, coexisting with EGFR mutations in some cases 52, 53.

It probably suggests that NF-kB is a downstream mediator of the GSK-3 signaling cascade.

The phosphorylation of insulin receptor substrates further promotes the activation of phosphotidylinositol 3-kinase and, subsequently stimulation of Akt and its downstream mediator AS160.

JNK is frequently a downstream mediator of TKR responses.

These results clearly implied that TG2 is a downstream mediator of TGF-β-induced EMT.

Similarly, the downstream mediator MyD88 [46], [46] was decreased at the protein level (Figure 4B).

Collectively, these studies demonstrate that ATF4 is a novel downstream mediator of PTH signaling.