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The two main downsides for FLOW-3D are its slow speed and high price.
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One of the main downsides of using silicone oil as an ocular tamponade is the need for a second surgery to remove the oil.
One of the main downsides of many established molecular docking algorithms is their inability to consider binding site flexibility [60].
Though, this doesn't account for the main downside of Airbnb: they tend to lack the consistency, privacy and freedom that would accompany a hostel private room or a hotel room -- because, well, usually you are in someone else's home.
If your daughter has a longer holiday than usual this year, then go earlier for the best prices and fewest crowds, the latter being the main downside of Italy at this time.
The main downside of this proposal is that taxes reduce economic activity.
The main downside of the technique is the higher level of complexity and computational effort.
The main downside of this sequential approach is that the pairings generated in the first step are not all suitable for the crew assignment step, yielding poor-quality solutions.
There are four main downsides to annuities.
However, there are two main downsides to manual segmentation.
The old system had two main downsides: it was not encrypted, and it prohibited communication between agencies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com