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The main downside of this proposal is that taxes reduce economic activity.
Then came the Turner prize; the main downside of which he described as being "in the Guardian five times in a week".
The main downside, of course, is that the higher rate and monthly payment remain in place through the life of the loan.
Listening to Night Thoughts, the main downside of this seventh Suede album is that it is an album by an indie rock band heavily influenced by Bowie, but not enough by Bowie's searching spirit and latterday musical courage.
If your daughter has a longer holiday than usual this year, then go earlier for the best prices and fewest crowds, the latter being the main downside of Italy at this time.
The main downside of the technique is the higher level of complexity and computational effort.
Similar(47)
One of the main downsides of many established molecular docking algorithms is their inability to consider binding site flexibility [60].
The crystallization challenge, low pressure, and low efficiency are the main downsides of bubble-pump-driven LiBr-H2O refrigeration systems, in comparison with other bubble-pump-driven diffusion absorption refrigeration systems.
The main downsides of residential DSL are the asymmetric bandwidth, which makes DSL face distance limited bandwidth issues as well as the asymmetric bandwidth constraints, and the cross talk, which is the interference between the copper lines in the same cable and is the main sources of data rate degradation in DSL.
One of the main downsides of using silicone oil as an ocular tamponade is the need for a second surgery to remove the oil.
This is the main downside to being friends with everyone – they all want a piece of your time.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com