Sentence examples for main dose limiting from inspiring English sources

Dose dependent and cumulative peripheral neuropathy is the main dose limiting side effect of chemotherapy with vincristine.

The haematological toxicity seen is in keeping with previous reports, which also reported myelotoxicity to be the main dose limiting factor [ 16, 31, 32].

Severe acute gastrointestinal toxicity (≥ grade 3) is the main dose limiting factor in patients receiving adjuvant three-dimensional conformal radiation therapy after surgery.

The maximum tolerated dose of the combination was established as: UFT® 350 mg m−2 day−1, LV 90 mg day−1, oxaliplatin 130 mg m−2, with grade 3 diarrhoea and grade 3 vomiting as the main dose limiting toxicities (DLTs).

In humans, late onset diarrhea (>24 h post CPT-11 treatment) associated with intestinal damage and decreased white blood cell counts, especially decreased neutrophil counts, are the main dose limiting side effects of treatment with CPT-11 (Rivory, 1996; Rothenberg et al, 1996, 1999; Rothenberg, 1998).

The primary dose limiting toxicity was hypertension.

Microtubule-targeting agents (MTAs), anticancer drugs widely used in the clinic, often induce peripheral neuropathy, a main dose-limiting side effect.

The kidneys are regarded as one of the main dose-limiting organs in the treatment of neuroendocrine tumours with 177Lu-[DOTA0 177Lu-[DOTA0oTyr3]-octreotateeotate), despite the successful use of kidney uptake blocking agents such as lysine and arginine.

The kidney is one of the most exposed organs after administration of 177Lu-octreotate, and despite the successful use of kidney uptake blocking agents such as lysine and arginine, the kidneys are regarded as the main dose-limiting organ (together with bone marrow).

The main dose-limiting toxicity was myelosuppression.

Neutropenia is the main dose-limiting toxicity for eribulin.