Obviously, regulation was more easily achieved with direct feedback so that the transfer might have presented the main difficulty for many children at the end of the training program and not the regulation itself.
The main difficulties came at left-back, where Everton's Leighton Baines had the sort of tough night that might get the name of Ashley Cole mentioned in the coming days.
The main difficulty in simulating diffusion processes at a molecular level in cell microdomains is due to the multiple scales involving nano- to micrometers.
If any such amendment were passed it could overcome the main difficulty the prime minister experienced at last month's EU summit.
At present, the main difficulty in hydrogen production via microbial anaerobic fermentation is the low yield of hydrogen.
This highlights the main difficulty with studies designed to look at single polymorphisms without knowledge of their functional significance.
Indeed, for short kinetic studies (30 sec to 1 minute) of highly unstable mRNAs, the main difficulty is to stop the reactions at the precise time point especially when multiple samples are processed simultaneously.
Since a beam theory incorporating higher-order deformations is available, the main difficulty is determining the exact matching conditions at the joint.
However, the main difficulty to providing care for families lies at present in the dearth of any family or child-focussed psychosocial services within oncology.
