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The phrase 'main differences among' is correct and usable in written English.
You could use it in a sentence like this: "The main differences among the various types of computer programming languages are their syntax and programming paradigms."
Exact(27)
The main differences among genotypes of different geographic origin were revealed in autumn phenology, when northern genotypes started earlier defoliation and bud-set.
Different variants of the response spectrum method exist, the main differences among them being related to the way of superposing the contributions of the three ground motion components and to the treatment of the simultaneity of physically distinct responses.
The main differences among the hypothesis introduced are related to the transportation field: different market regulations, fiscal and infrastructural policies, prescriptions and bans.
The main differences among arrangements of the same group reside in the presence/absence of different ISs (either complete or partly deleted), some insertions/deletions (indels), and/or repeat sequences (fig. 6).
Here are the main differences among them.
The design and function of this center differential are the main differences among the all-wheel-drive systems available today.
Similar(33)
The main difference among calves originates from different BWs causing variations in lean tissue weight.
The main difference among the services is that each sells tickets for different theater chains.
The main difference among various layouts is the dehumidification process.
The main difference among these methods was the influence of ions on film formation.
The main difference among these PMGs is the method used to concentrate the magnetic flux.
More suggestions(14)
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com