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"main difference with" is correct and usable in written English.
You can use it when you want to indicate that there is a difference between two things. For example: "The main difference with this new method is that it is more efficient."
Exact(60)
The main difference with FRP confined columns is related to the different post-peak behaviour, characterized by a softening branch.
The main difference with other smartwatches is the circular screen.
The main difference with P.S.G., however, is the lack of a strong domestic foundation around the club.
This is the main difference with the local TV model.
The main difference with DGKD is the metrics.
This is the main difference with the approach in [14].
But the main difference with Prezi is that it's all HTML5.
But the main difference with Circle Invest is that the new service doesn't have any fee.
But first, let's start with the main difference with iOS 10.
The main difference with YouTube is that it's 100percentt user generated content.
The other main difference with industry is the emphasis on the two-way selling process.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com