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Oxygen exposition causes the emergence of the two main deleterious phenotypes observed in the yeast Δ yfh1 mutant; iron sulfur cluster deficiency and oxidative stress.
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Next, dsRNAs were made for C. pomonella genes orthologous to those that have well defined deleterious phenotypes in Drosophila melanogaster.
The deleterious phenotypes obtained due to NLP knockdown suggests that transgenic plants engineered to express RNA constructs targeting nlp genes may emerge as an environmentally viable option to manage nematode problems in crop plants.
Next, seven of these sequences for which deleterious phenotypes (e.g. lethal, paralyzed, movement abnormal, etc).
One would expect that loss of function in MIRO2 alone would result in deleterious phenotypes at these developmental stages.
Importantly, long-term inhibition of calpains did not result in any overt deleterious phenotypes in mice.
Mutations in WDR62 are found to cause deleterious phenotypes such as microcephaly and pachygyria [ 10, 22, 23].
In summary, while some mutations in this region can be well tolerated in bacteria, others result in deleterious phenotypes.
Mutations in WDR62 have been found to cause deleterious phenotypes such as microcephaly and pachygyria [ 10, 22, 23].
By contrast, an insertion of GFP or tdEOS within the unstructured N-terminal tail of Cse4 avoids such deleterious phenotypes.
Thus, one may expect that, on average, rare variants will be more likely to be associated with deleterious phenotypes.
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