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The main common diseases to tackle in those regions are lower respiratory infections, diarrheal disease, preterm birth complications and tuberculosis as well as malaria and HIV/AIDS for the African and cardiovascular disease for the Eastern Mediterranean regions [ 40, 41].
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It is hypothesized that interactions between disease susceptibility genes with minimal main effects will be the norm rather than the exception for many common diseases [ 2, 5- 7].
Importantly, the disturbance in insulin signaling appears to be the main common impairment in both diseases [ 12- 15].
For most common diseases, the main genetic effects are expected to be small and therefore would require very large studies to capture [7].
One of the main assumptions of current GWAS is that common diseases are caused by at least a few common genetic variants of relatively large effect (the common disease, common variant [CDCV] hypothesis).
Note, that the architecture of the genetics of gene expression is reported to be in the main additive, thereby closely resembling those of common diseases (62).
We consider here five main common characteristics and requirements, respectively, regarding climate-sensitive infectious diseases: Exposure to new patterns of climate-sensitive infectious diseases.
The prevalence of allergic diseases in mothers is presented in Table 2. Asthma and allergic rhinitis were the most common diseases and dust mite allergens the main sensitizers.
Many of the main challenges facing modern health care arise from the complex and heterogeneous characteristics of common diseases.
The main aim of this study was to identify the epidemiologic characteristics and clinical courses of these common diseases in Hamadan, Iran.
"We want the most common diseases of the poor.
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