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The present paper describes the approach developed by the authors to meet the need for treatment following the London bombings in those people reporting clinically significant travel avoidance as their main clinical problem.
The main clinical problem of cystinuria is the possibility of cystine stone formation in the kidney; unlike lysine, arginine, and ornithine, which are freely soluble, cystine is only slightly soluble in urine, and when urine volume decreases, particularly at night, this amino acid may form stones.
The complications associated with prosthetic failure and revision surgery still constitute the main clinical problem.
Cardiovascular complications are the main clinical problem in patients with end-stage renal failure (ESRF).
P. aeruginosa infection is a main clinical problem in various immunodeficiency conditions such as HIV, severe burns, and cancers.
We suggest that the main clinical problem arises when the bull mounts and the patella slides over the trochlea.
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The main clinical problems in RS infants are upper airway obstruction and feeding difficulties.
Long term exposure to ARVs give rise to the main clinical problems.
When a patient presents haemoptysis the main clinical problems explored are infections, tumors, bronchiectasis, malformations, vasculitis, coagulative defects [ 1].
Patients with end-stage renal disease undergoing haemodialysis commonly suffer from malnutrition, which represents one of the main clinical problems for these patients.
Many efforts have been, indeed, recently devoted to find out strategies which might improve permeability of BBB to CNS-directed drugs (for review see [ 68]), although, paradoxically, BBB leakage and the concomitant vasogenic edema (see below) are the main clinical problems in patients suffering from glioblastoma (for review see [ 69]).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com