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There are three main clinical forms; visceral, cutaneous and mucocutaneous [1].
To identify gene patterns specifically altered in DSS patients, we compared three groups of carefully matched paediatric patients representing the main clinical forms of symptomatic dengue infections DF (n = 16), DHF (n = 13) and DSS (n = 19), according to the 1997 WHO classification criteria of dengue severity [29].
Leishmaniasis is a complex of diseases that has 3 main clinical forms, visceral, mucocutaneous, and cutaneous.
The main clinical forms of tegumentary leishmaniasis are cutaneous leishmaniasis (CL) and mucosal leishmaniasis (ML).
Globally, prostration, neurological symptoms like seizures and pallor are the main clinical forms of malaria among children with acute febrile illness as observed in other endemic countries [ 25, 26].
Candida is the most common fungal pathogen in ICU patients, and the main clinical forms are bloodstream infection, followed by peritonitis and other abdominal infection, endocarditis, and so forth.
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A low number of individuals develop pneumonia, which is the main clinical form in immunocompetent patients (primary pulmonary histoplasmosis) with distinctive histopathological features, like chronic granulomatous infiltrate [ 69].
Our study comprised over 200 cultures from patients living in 14 out of 26 Brazilian states, representing the main endemic areas and clinical forms of the disease.
The main clinical manifestation of the chronic form is culture-negative endocarditis, but infection of vascular grafts or aneurysms, hepatitis, osteomyelitis, and prolonged fever have also been described (1, 2 ).
Different prion strains in cattle appear to produce two main clinical phenotypes (dull and nervous form), with classical BSE being the most uniform and - with respect to over-reactivity - clinically the most extreme phenotype.
In the literature, this complex phenotype is divided into three grades (mild, classic, and severe) and four or five main clinical categories (congenital, infantile/juvenile, adult-onset and late-onset forms), according to symptom severity and age of onset, respectively.
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