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"main challenges of" is a perfectly correct and usable part of a sentence in written English.
For example: "One of the main challenges of running a successful business is managing the ever-changing regulations."
Exact(60)
The main challenges of our times are the rise in inequality and global warming.
Answering that question is one of the main challenges of the Syrian revolution.
The main challenges of dynamic estimation in large power systems are also addressed in this paper.
Trade policy with Asia will be one of the main challenges of the new administration.
Efficient and reliable calibration was one of the main challenges of this project.
The main challenges of biological implants are suitable strength, adhesion, biocompatibility and corrosion resistance.
One of the main challenges of automotive vehicle longitudinal control is integrating throttle and brake control.
The main challenges of thermal issues on stratospheric airships are analyzed.
The case highlights one of the main challenges of doing business with companies from fast-growing and resource-rich Indonesia.
This chapter will presents the current status and the main challenges of biomass logistics.
Studying and understanding human brain is one of the main challenges of 21st century scientists.
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CEO of Professional Science Editing for Scientists @ prosciediting.com