Indeed, the entire S-RNase main-chain frame works superimposes well with T2- RNases, in particular the core structures composed of three α-helices and four β- strands.
In the Figure 4 main chain parameters are given.
The clamp that holds the main chain will be located on the vertical of the protruding corner of the frame.
The main chain conformation of FUS (37 97) is shown.
The side-chain mesogens are packed around the main chain with their axes almost perpendicular to the main chain.
The side-chain of N313 coordinates Na+3, while its main chain carbonyl binds Na+1 (Fig. 4b and Supplementary Fig. 3).
However, instead of the main chain carbonyl of Ala1049, the -enantiomer is hydrogen bonded to the main chain carbonyl of Arg1047.
This chain extension and less stiff main chain were more significantly observed for the cyclic chains.
Main chain atoms only are shown.
Connection character '-' for bonding of the main chain.
Proteins are dynamic entities, with significant motions of both the main chain and side chains.
