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The interactions between the main cellular sources of ROS, such as mitochondria and NADPH oxidase, are known to play an imperative role in the pathogenesis of hyperoxaluria-induced nephrolithiasis.
The main cellular sources of CXCL12 are resident stromal fibroblasts and epithelial cells.
Complex I is one of the main cellular sources for reactive oxygen species (ROS) and we have shown that metformin can prevent ROS production by senescent cells [ 8].
Although the main cellular sources of IL-1 have been extensively studied, the relative contributions of central and peripheral (blood -derived IL-1 to blood -derivedave not been investigated.
We found that the main cellular sources of CCL5 were epithelioid histiocytes, multinucleated giant cells, surrounding alveolar macrophages and a minor component was other inflammatory mononuclear cells that formed the non-necrotizing granulomas.
We found that at all stages of pulmonary sarcoidosis including those with or without alveolitis and those on or off immunosuppressive therapy main cellular sources of CCR1, CCR2, and CCR3 were epithelioid histiocytes, multinucleated giant cells and other infiltrating mononuclear cells that formed the non-necrotizing granulomas.
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We conclude that activated microglia together with other glial cells in the marginal zone after MCAO are the main cellular source of ETs that may be involved in regulation of vascular constriction and glial chemokines/cytokines production.
Mitochondria are main cellular source for energy in eukaryotic cells.
Neutrophils are the main cellular source for α-defensins1-3, which are also designated human neutrophil peptides (HNP1-3)[4], although other leukocyte subsets also produce them[2], [5] [7].
Thus, these results indicate that radio-resistant non-hematopoietic cells constitute the main cellular source of TNF in the pathogenesis of PF.
A more detailed study is required to establish the main cellular source of NO in malaria patients and to determine whether HZ is at least in part responsible for such event.
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