This would explain the numerous changes in expression of genes associated with energy creation within the cell (Fig. 5C, 5D) and appears to constitute the main cellular response to LC-uFFAs.
Among the enriched set of genes shown in Figure 1, approximately 30% have membrane-related functions based on Gene Ontology (GO) terms (whereas around 17% of the currently annotated E. coli genes are membrane-related), which corresponds with the main cellular response to the presence of other organic solvents [13], [23] [25].
Dear Editor, The unfolded protein response (UPR) constitutes the main cellular response to perturbed protein homeostasis.
The pronounced determinant of PC3 making them distinct from other cells used here is lack of active p53 [ 57] that mediates main cellular response to DNA damage.
Consistent with others [ 31], we observed that the cell death induction of 5-FU is not very impressive, with apoptosis as a main cellular response to treatment with 5-FU.
As MGMT is depleted at this time point, we hypothesise that the main cellular response to AOM involves the early depletion of MGMT then a switch to the induction of apoptosis and this most likely first occurs through the p53 signalling pathway.
Firstly, based on their findings, it would appear that the main early cellular response within the pouch lining, and by inference the synovial lining, is from cells of the macrophage lineage or type A cells.
One of the main hypoxia-induced cellular responses is autophagy, a lysosomal-mediated degradation pathway used to survive starvation and stress.
Here we extend on previous work and report on the construction and evaluation of a mechanistic network model focused on DNA damage response and the four main cellular fates induced by stress: autophagy, apoptosis, necroptosis, and senescence.
We constructed a network model focused on DNA damage response and the four main cellular fates induced by overwhelming stress: autophagy, apoptosis, necroptosis, and senescence (Fig. 1, Supplementary Fig. 1).
