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Figure 1 The main cellular processes.
Conceptual representation of the main cellular processes that occur inside the cell.
This indicated that main cellular processes, such as the cell cycle and protein synthesis/transport were disrupted, leading to protein degradation through ubiquitine mediated proteolysis.
This clearly demonstrated association of these transcripts with the main cellular processes linked to cancer, including proliferation, apoptosis and DNA damage repair (Table 3).
Transcripts were assigned gene ontologies, which were then grouped by function to determine whether the transcripts recovered from the meta-assembly were representative of the main cellular processes.
Therefore, it is very important to discover the exact mechanisms that determine the PI3K/AKT signaling activity and to understand how the inhibition of this pathway influences the main cellular processes.
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Because any drug alone or in combination did not induce any modulation of GST activity, we focused on oxaliplatin DNA adduct repair whose main cellular process is the NER.
The nucleotide excision repair (NER) is the main cellular process involved in the elimination of oxaliplatin DNA platinum adducts (Chaney et al, 2005) where excision repair cross complementation group1 (ERCC1) is the key enzyme leading to the 5′ incision of the platinum DNA damage (Reed, 1998).
The main categories "Cellular Processes" and "Environmental Information Processing" were merged into "Cellular Processing and Signaling".
Classification according to protein function encoded by these 31 genes showed that the main regulated cellular processes during this differentiation were (i) remodeling of the extracellular matrix, particularly, sulfated structures, (ii) down-regulation of O-mannosyl glycan biosynthesis, and (iii) an increase in adhesion protein expression.
The main terms (cellular process, immune response, metabolic process, transport, response to stimulus, system process, and developmental process) have been compiled using the Gene Ontology search function [21, 22].
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