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Because any drug alone or in combination did not induce any modulation of GST activity, we focused on oxaliplatin DNA adduct repair whose main cellular process is the NER.
The nucleotide excision repair (NER) is the main cellular process involved in the elimination of oxaliplatin DNA platinum adducts (Chaney et al, 2005) where excision repair cross complementation group1 (ERCC1) is the key enzyme leading to the 5′ incision of the platinum DNA damage (Reed, 1998).
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Figure 1 The main cellular processes.
Conceptual representation of the main cellular processes that occur inside the cell.
This indicated that main cellular processes, such as the cell cycle and protein synthesis/transport were disrupted, leading to protein degradation through ubiquitine mediated proteolysis.
This clearly demonstrated association of these transcripts with the main cellular processes linked to cancer, including proliferation, apoptosis and DNA damage repair (Table 3).
Transcripts were assigned gene ontologies, which were then grouped by function to determine whether the transcripts recovered from the meta-assembly were representative of the main cellular processes.
Therefore, it is very important to discover the exact mechanisms that determine the PI3K/AKT signaling activity and to understand how the inhibition of this pathway influences the main cellular processes.
Because many of the CGIs overlap with TSSs, these two studies suggest that CGIs are associated with five substitution patterns that are the mutational signatures of the main cellular processes in human germ cells.
Herein, we describe the main cellular processes taking place at the M-region, other than thick filament assembly, and discuss human myopathies associated with mutant or truncated M-region proteins.
The known miRNA : target interactions in melanoma and their implications in main cellular processes identified in the course of the studies cited in this paragraph are presented in Figure 2. Ozsolak et al (2008) identified promoter regions of 175 human miRNAs by combining nucleosome mapping with chromatin signatures for promoters.
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