The main cellular immunity pathways are the Toll, JAK/STAT, and JNK pathways (Meister 2004), but it is not clear whether selection pressures imposed by parasites may have driven diversification patterns in these pathways similar to those found in the humoral pathways.
To decipher further the mechanism of action of this compound in CML cells, we analyzed the effect of a panel of pharmacological agents known to inhibit the main cellular signaling pathways including p38MAPK, JNK, ERK1/2, PI3K, mTOR, PKA, PKC and the caspase cascade.
In particular, generalised statements on whether apoptosis susceptibility will be enhanced or decreased by modulating the main cellular proteolytic pathways may not be warranted.
Two distinct Yap1 regulons were defined in S. cerevisiae, covering oxidative stress response, the second involved in the metabolic pathways regenerating the main cellular reducing power, GSH and NADPH [14].
We describe a novel approach for systems-level interpretation of microarray expression data using a manually constructed "overview" pathway depicting the main cellular signaling channels (Atlas of Signaling).
In conclusion, we have developed a novel approach for a systems-level interpretation of microarray expression data in the context of manually constructed "overview" pathway depicting the main cellular signaling channels.
Therefore, it is very important to discover the exact mechanisms that determine the PI3K/AKT signaling activity and to understand how the inhibition of this pathway influences the main cellular processes.
The two main cellular protein degradation systems are the autophagy pathway and the proteasome system.
Grouping proteins into functionally coherent groups (either by protein families performing similar functions or by participation in common cellular processes) and connecting these groups by well-established biological regulatory links into a single overview pathway (Atlas of Signaling) depicting main cellular signaling channels.
