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Protein synthesis, apoptosis, cellular movement, growth and proliferation were the main cellular functions associated with the modulated genes.
Unexpectedly, the global analysis of gene functions reveals that two main cellular functions, protein metabolism and chromatin structure/transcriptional regulation, could be deregulated by v-ErbA.
Data mining analysis showed that protein synthesis, apoptosis, cellular movement, growth and proliferation were the main cellular functions significantly associated with the modulated genes (p < 0.05).
Src family kinase (SFK) proteins regulate four main cellular functions that ultimately control the behaviour of transformed cells: cell proliferation, adhesion, invasion, and motility (Summy and Gallick, 2003; Yeatman, 2004).
The use of functional annotations (mainly Gene Ontology (GO) annotations) allowed us to find that many v-ErbA repressed target genes are involved in two main cellular functions: chromatin structure/transcriptional regulation and protein metabolism.
Genes identified through microarray analysis (focus genes), network score (probability of network being assembled by chance alone), and main cellular functions of the network are listed in Table 5.
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The main cellular function of MDM2 is to regulate p53 levels.
Since the Goldengate Cancer Panel quantifies methylation of cancer-related genes with various functions, we first subsetted genes associated with our main cellular function of interest, tumor suppression.
Protein synthesis, apoptosis, cellular movement, growth and proliferation are the main significant cellular functions (p < 0.05) that are associated to the modulated genes.
ROCK is the main downstream effector of Ras-homologous (Rho) family of GTPases which are involved in many cellular functions, such as cell proliferation, invasion and metastasis.
Natural methylation has many cellular functions.
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