Sentence examples for main cellular and from inspiring English sources

Envisaging a novel rationale for an effective therapy, the current review summarizes the main cellular and molecular mechanisms underlying cisplatin resistance and the impact of chemotherapy challenge in CSC selection and clinical outcome.

To a large extent this has been associated with lack of any particular need to equate the usual sequence of inflammation and repair that accompanies the introduction of biomaterials into a host site with the innate immune response, even though the main cellular and humoral features of the latter were usually evident in the former.

We were able to build FIRM based on a reconstructed network of the main cellular and molecular components involved in the immune response.

The new hypothesis of protein glycation and that of oxidative stress and mitochondrial dysfunction, which are closely related to calcium regulation, are considered to be the main cellular and molecular mechanisms underlying aging of the ovarian follicle [ 21].

GSH is a thiol-containing coenzyme that plays a relevant role in several redox reactions in the body, including the maintenance of the thiol properties of reduced coenzyme A, cysteine and vitamins C and E. GSH is the main cellular antioxidant, and is found at concentrations of between 1 and 10 mM in most mammalian cells, including neurons.

In contrast, type 35 Ad (Ad35) use CD46 molecules as a main cellular receptor and expressed levels of CD46 are well maintained even in human tumors [ 4, 5].

Adenosine monophosphate-activated protein kinase (AMPK) is the main cellular energy sensor and actively participates in the interaction between metabolism and cancer.

Taken together, the centrosome is a truly central and main cellular station that directs, coordinates, and regulates most cellular functions either directly or indirectly through its microtubule organizing capabilities.

The 10%% of the highest constitutively expressed genes for all carbohydrate treatments (163 genes) were assigned Clusters of Orthologous Groups (COG) categories [ 27] and emphasized main cellular functions of growth and energy turn-over.

Figure  5 shows the patterns and mutual localization of five simultaneously labeled antigens on such composite image, with main cellular compartments delineated and nanoparticles color-coded.

Inactivation of wild type P53 by its main cellular inhibitors (MDM2 and MDMX) is a well recognised feature of tumour formation in liposarcomas.