Bone marrow mesenchymal stem cells (MSCs) have become the main cell source for bone tissue engineering.
Mesenchymal stem cells (MSCs) from bone marrow are main cell source for tissue repair and engineering, and vehicles of cell-based gene therapy.
Should hUCB-MSCs have a superior effect on wound healing as compared with fibroblasts, which are the main cell source in current cell therapy products for wound healing, they may possibly replace fibroblasts.
Although Schwann cells (SCs) and bone marrow derived mesenchymal stromal cells (BM-MSCs) are the main cell source for nerve tissue engineering, the clinical application is limited because of donor site morbidity, the invasive procedure, and the decreased number of SCs and BM-MSCs.
Interestingly, microglial cells, which are the main cell source of IL-1β in the brain [2], express P2X7R [11], [11].
Within the joint, chondrocytes may be the main cell source of NO, and iNOS expression is increased in human OA cartilage [ 29].
Because RPE is a main cell source producing PEDF in the eye, RPE abnormality could be responsible for decreased PEDF expression in the retinas of the DKO rd8 mouse.
In this review we describe, from an engineering perspective, progress in the field of liver tissue engineering, including three main aspects involving cell sources, scaffolds and vascularization.
Tissue engineering is a multidisciplinary field that is affected by three main agents including cell source, scaffold biomaterial, and biochemical agents.
