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SIR —Your article on global public health is absolutely right in identifying health system weaknesses as the main bottleneck to more efficient aid programmes.
However, we are witnessing the era of big data computing where computing resources are becoming the main bottleneck to deal with those large datasets.
In this setting, insufficient access to HIV testing was identified to be the main bottleneck to prevent MTCT.
The main bottleneck to ab initio protein structure calculation methods is that the size of the search space is intractable.
The lack of HRH in Swaziland is widely regarded as the main bottleneck to scaling up ART and maintaining thousands of patients on ART over time.
Nevertheless, it is to be expected that, as these factors are more clearly recognised, discovery and validation processes might be improved to a point where they are no longer the main bottleneck to progress.
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However, as with most marine fish species, larval culture and adequate weaning are still one of the main bottlenecks to successful commercial production.
The main bottlenecks to purified HM were therefore low solubilization of HM IBs or purification losses.
In each workshop, after participants had identified the main bottlenecks to each tracer intervention for each health system building block, they came to consensus and graded the severity of the bottlenecks within each health system building block.
Leadership really does matter but can you make better leaders?" (KI 5) KIs also identified weak health systems as one of the main bottlenecks to scaling up proven interventions and to reaching the MDGs (KIs 5, 12).
Despite of some progress in developing computational methods for NMR data processing, the main bottlenecks to analysis of NMR spectroscopy data remain, i.e., solving structures of large proteins and solving loop structures.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com