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Most of the genes whose expression was affected by contact with the probiotic at a MOI of 10 were involved in four main biological processes: 1/ immune and inflammatory responses, 2/ antigen processing and presentation via major histocompatibility complex class (MHC), 3/ intercellular signalling and 4/ signal transduction (figure 1A).
Interaction studies between small molecules and DNA are essential for rational drug designing to influence main biological processes and also introducing new probes for the assay of DNA.
In the present investigation, the regulated biological functions were classified under seven different main biological processes (cellular process, immune response, metabolic process, transport, response to stimulus, system process, and developmental process).
The identification of protein-protein interaction networks in living cells is becoming increasingly fundamental to elucidate main biological processes and to understand disease molecular bases on a system-wide level.
Functional analyses of all DEGs highlighted the protein ubiquitination pathway and DNA damage response (DDR) network being the two main biological processes in common in the two cell types.
More clearly, the 13 overrepresented functional clusters confirm the main biological processes.
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There are clusters that share the same main biological process and QAPgrid is able to assign them in contiguous locations in the grid.
The main biological process affected based on gene expression analysis was lipid metabolism.
GO-term enrichment analysis confirmed that acute inflammatory response is the main biological process responsible for such differentiation.
Both of these studies report the alteration of genes involved in lipid metabolism the main biological process altered during SNEB.
Among them, 27 GO terms were picked as they can be grouped into three main biological process categories (Table 3).
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basic biological processes
primary biological processes
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mainly biological processes
main biological concepts
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main biological assumptions
main standardized processes
main biological questions
main cellular processes
main biological functions
main biological components
main biological mechanisms
main biological markers
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