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Based on the main (biological) effect of interest, that needs to be investigated using an imaging experiment, select the proper imaging modality.
Based on the main (biological) effect of interest, that needs to be investigated using an imaging experiment, a correct animal model needs to be selected.
Although, E. platyloba is a plant with many pharmacological effects but the main biological effect is their antifungal and synergistic effect with azole drugs against Candida albicans infections in vitro and in vivo studies.
The main biological effect of NAC as a precursor of cysteine is to replenishing cellular GSH levels and to preserve the thiol redox status.
These isoforms retain at least part of the DNA binding and oligomerization capabilities, but differ through regulatory domains in the N- and C-terminus, supporting the notion that their main biological effect is to modulate p53 protein functions.
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On the other hand, Oppman et al showed that the main biological effects of IL-23 can be observed on survival of memory Th17 cells and not on naïve T cells [13].
Overall, these results suggest that Δ40p53 exerts its main biological effects by modulating the activity of full-length p53.
To investigate the main biological effects induced by growth medium (proliferation effect), and the sustained effect of the inhibitor, GSEA was performed with entire contrasts.
There are two main biological effects of ionizing radiation: stochastic effects, which include carcinogenic and genetic effects and deterministic effects (also called tissue reactions), which refer to an immediate and very predictable change to the tissue [ 14].
To investigate the main biological effects regulated by CS in AIR-100 tissue cultures, GSEA was performed with entire contrasts computed for the treatment effect independently of the dose.
Aiming to assess the biological relevance of Chok-alpha expression and activity in EOC cells, here we specifically silenced CHKA gene expression by transient RNA interference in two EOC cell lines and evaluated the main biological effects related to alterations of tCho-metabolic profiles, global gene expression as well as general cancer cell behaviour.
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