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The two sets showed remarkable similarities and clear differences from the morphology of present-day Amerindians and were interpreted as new evidences for the Two Main Biological Components Model advocated by them.
However, despite the two main biological components affirmation, facial flatness is absent among Late Holocene South American groups [40], [43].
This hypothesis, known as two main biological components, asserts that the morphological diversity of American human populations results from two successive migratory events.
Conversely, the same morphological differences were also observed in other regions of South America and have been used as evidence of different migratory waves, according with the two main biological components hypothesis, with a major population replacement taking place around 8,000 3,000 years BP [8] [10].
The craniofacial comparison of these samples with samples displaying Amerindian like morphologies as those assigned to Later Late Holocene from Perú has been used up till now as evidence supporting the existence of two main biological components in the peopling of America [9].
Alternatively, if we consider the hypothesis of two main biological components, and a major replacement of Paleoamericans by Amerindians during the Middle or Earlier Late Holocene, the "invading" population (i.e. Amerindians) could have had a genetic exchange with the local population (i.e. Paleoamericans).
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Although Cantonese-style salted fish has been classified by IARC as a group 1 carcinogen [ 9], the putative main biological active component N-nitrosodimethylamine, is only classified as a group 2A carcinogen [ 13].
Indeed the overall aim of this paper is (i) to support researchers in search of new genes responsible for NSHL and (ii) provide indications about the main biological processes, molecular functions and cellular components to be explored to study NSHL, by defining a procedure to computationally prioritize candidate genes for their association with this phenotype.
Gene ontologies [ 79] and EC number from KEGG pathways [ 80] were retrieved to identify the main biological processes, molecular functions, and cellular components present in the GIs.
The main goal of synthetic biology is to understand, design, and construct novel biological components to rewire organisms or even to create a new life [ 4].
The main biological functions of lipids include storing energy, signaling, and acting as structural components of cell membranes.
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