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Recently, we established the α2 chain of collagen type VI as the main binding structure for sequestration of collagenases and stromelysin-1 proforms in fibrotic tissue [ 15].
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The 48scFv binds distant from the main binding pocket and may also show reduced affinity compared to its parental antibody [ 47], since scFv usually exhibit reduced avidity due to their monovalent structure.
X-ray diffraction (XRD) patterns were calculated and compared to literature data with the aim of investigating the crystal structure of nanocrystalline calcium silicate hydrates (C-S-H), the main binding phase in hydrated Portland cement pastes.
Considering that the main binding site of hTFIIEα AC-D is located on the N-terminal tail outside the core structure, Tfa1 does not seem to have a similar core AC-D structure, but the interaction with PH-D is likely to be conserved.
In the 19th century Portland cement, a fine artificial powder, was the main binding agent in concrete.
The authors conclude a subsite binding of the second peptide unit close to the main binding pocket.
The binding structures were investigated by using FTIR spectroscopy.
The main defensive structure is a revetted lunette shaped earthwork.
Thus, experimental evidence indicated the presence in the main structure of HS of metal-binding sites such as salicylic-, phthalic- or catechol-type [3, 11] (Fig. 3).
In both the locked and unlatched structures, the main PtdIns4,5P2-binding site on the α subunit and the [ED]xxxL[LI] motif-binding site are adjacent to each other and located on what was consequently proposed to be part of the AP2 membrane-interacting surface, but the YxxΦ motif-binding site is located on an orthogonal face.
Nevertheless, there is no doubt that the main C1q binding site is located in close proximity to Lys, Pro, and Pro 22 in agreement with the results of crystal structure studies, suggesting a critical role for the hinge region of human IgG1 in C1q binding 16.
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