Sentence examples for main binding pocket from inspiring English sources

The 48scFv binds distant from the main binding pocket and may also show reduced affinity compared to its parental antibody [ 47], since scFv usually exhibit reduced avidity due to their monovalent structure.

The authors conclude a subsite binding of the second peptide unit close to the main binding pocket.

The main binding pocket of F-MuLV to its cellular receptor remains unaffected, red) and is consistent to the data of the ICA in presence of 48scFv-SCR-constructs without NMS, since no reduction in infectivity is revealed.

In any case, the two studies firmly establish that a collection of residues facing the main binding pocket of EBI2 are crucial to 7α,25-OHC binding of which Arg87, Asn114, Tyr116, and Tyr260 are of particular importance (Fig. 2B and D).

For each subunit, there is a main agonist binding pocket, denoted as the primary face, which includes four of the five residues that make up the canonical "aromatic box".

We observed important polar interactions between the carboxylic group and main residues into the binding pocket.

In addition, LPF, LVM, PFF, SID and CW form the main part of the binding pocket in the 3D structure of a GPCR, i.e. β2-adrenergic receptor bound to carazolol (Fig. 5), where 'F' of PFF and 'D' of SID are important in ligand binding from mutagenesis studies [13].

Moreover, as shown in Figures 1A and 1B, compared with the functional area reported by Kuwata, we found that the predicted switch region corresponded exactly to the main body of the binding pocket for GN8, which means our prediction is quite accurate.

No correlation between the closing of the cap and the observed open or closed states of the proposed glycerol exit hole could be observed in our molecular dynamics calculations of bMGL: In one of the simulations, the glycerol exit hole stayed open, whereas in other cases, the exit hole closed independent of the open or closed state of the main entrance of the binding pocket (Fig. S7).

As in all lipases, the active site of CalA is made up of two main substrate binding pockets; an acyl binding pocket and a nucleophile (or alcohol) binding site.

The eight to ten amino acid residues forming the adenylation domain binding pocket are the main determinants of substrate specificity [ 7, 61, 62].