Sentence examples similar to main binding mode from inspiring English sources

The simulations therefore strongly suggest that the ManNAc binding mode in wild-type NAL is the main contributory factor to the high stereoselectivity reported.

Arg168 forms the base of the phosphopeptide binding site, making hydrogen bonds with main-chain atoms of the bound ligand in a manner reminiscent of the binding mode observed in BRCA1 C terminus phosphopeptide complexes (BRCA1 Arg1699 and MDC1 Arg1933) (Clapperton et al., 2004, Stucki et al., 2005).

Starting from classical homology and docking approaches, binding mode hypotheses are created for five agonists of the nAChR, covering insecticides in the main group 4 of the Insecticide Resistance Action Committee (IRAC) mode of action (MoA) classification, namely, neonicotinoids, nicotine, sulfoxaflor, and butenolides.

This putative binding mode was used as a starting point for the rational design of inhibitors exploring two main areas in the binding site: the hydrophobic gatekeeper region and the lipophilic pocket leading to solvent (the region next to Gln 85 in Figure 4).

The main point of the design was to fill the interdomain cavity of GluA2 ligand binding domains based on the cyclothiazide binding mode.

b 2D binding mode found from XP P1. c 2D binding mode found from XP P1.

b 2D binding mode from SP P1. c 2D binding mode from SP P1.

This means that the RNA binding mode is preserved.

complex binding mode of carbamazepine with the HLA-B*15:02 variant.

Docking cannot be considered conclusive for the binding mode.

The binding mode of 5l is represented in Fig. 1a.