Sentence examples for main binding funnel from inspiring English sources

We focus on the main binding funnel in a neighborhood of the native state, which is the most important region of the conformational space, containing over 90% of complex structures observed in the PRE experiments (Iwahara and Clore, 2006; Tang et al., 2006; Clore and Iwahara, 2009; Fawzi et al., 2010).

In the 19th century Portland cement, a fine artificial powder, was the main binding agent in concrete.

Landscape representation at different resolutions can be used for the refinement of docking predictions and detection of macro characteristics, like the binding funnel.

In the example described below we focus on the properties of the true positive binding funnel and calculate mean first-passage times between distinct conformational states within the funnel, i.e. we are interested in finding the favourable transition path from the top to the bottom of the binding funnel.

For the first example (analysis of a protein-protein binding funnel), due to the large number of cycles within the network, the Monte Carlo method was applied.

These changes most likely result in active site endpoint interactions affecting drug binding affinity and could disturb the proposed electrostatic binding funnel instrumental in directing NAIs into and out of binding sites on NA (14 ).

Here we are interested in finding the favourable path(s) between incorrect conformational states (ID 9 and 30; states on the edge of the binding funnel) and the best state found by SwarmDock (the state closest to the bottom of the binding funnel; the native complex state).

In conclusion, by exploring MFPTs between conformational states within a protein-protein binding funnel, dynamic information can be obtained that may provide important complementary, and sometimes counter intuitive, information on the funnel's physical properties, which may facilitate rational design of competitive protein ligand inhibitors.

The two main binding proteins are the cortisol-binding globulin (CBG) and albumin [ 1].

The above study, based on state occupancies, was useful in distinguishing between true positive and false positive binding funnels.

Studying the topological properties of protein-protein binding funnels will enable us to understand how to change the dynamics of protein-protein association in a controlled way.