Sentence examples for main binding determinants from inspiring English sources

Therefore, a mutational analysis of BMPR-IA was performed in order to see whether the functional epitopes, i.e. the main binding determinants for the interaction with both binding partners, are similar.

Two of these three clusters include the so-called main binding determinants, Glu9 (IL-4) and Arg88 (IL-4), which contribute about 80% of the total binding energy.

Mutagenesis studies reveal that IL-13 utilizes the same main binding determinants, i.e. Glu11 (cluster 1) and Arg64 (cluster 2), suggesting that IL-13 also uses this modular protein interface architecture.

The fact that most of the residues contained within HGF 681 698 are buried in the interior of HGFβ chain and lack the main binding determinants such as Y673 makes the binding of this peptide to MET extracellular domain unlikely to occur.

Compared with the apparent affinity of wild-type IL-13, the affinity drops by factors of 230 and 1300 for IL-13 E11andnd IL-13 R64A, showing that although the affinity of IL-13 for IL-4Rα is 1000-fold lower than that of IL-4 for IL-4Rα, both main binding determinants are conserved.

We believe the strategy can be applied to evolve the specificity of other antibodies because, like Herceptin, many natural antibodies utilize the heavy chain (HC) CDRs as the main antigen binding determinants, and therefore can tolerate some mutation in the LC CDRs.

Moreover, the main tRNA binding determinant of Ec ProRS is the anticodon interaction, and therefore any contribution of K279 to binding/positioning of the 5′-CCA-Ala end of the tRNA is difficult to measure and quantify.

One possibility is that insulin-like growth factor (IGF) and its main binding protein IGF-binding protein-3, themselves and their genetic determinants both of which have been related to breast density (Guo et al, 2001; Maskarinec et al, 2003; Tamimi et al, 2007), may play a role.

VHL has two well-defined TRiC binding determinants.

The region of p65 binding was further narrowed to identify specific binding determinants (data not shown).

However, their IgE-binding determinants remain unknown.