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Two main apoptosis pathways have been identified.
Cancer cells can resist apoptosis if they have an overexpression of antiapoptotic proteins, involved in the two main apoptosis pathways, extrinsic and intrinsic.
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Defective apoptosis pathways are main causes of trastuzumab resistance.
The main differences lay in the cell cycle and apoptosis pathways.
Other genes regulating apoptosis pathways are often altered in lung cancer such as RasSF1, the main tumor suppressor gene on 3p chromosome and the DAP kinase gene.
Apoptosis can be activated via either the death receptor-mediated apoptosis pathway, the mitochondria-dependent apoptosis pathway or endoplasmic reticulum (ER) stress-induced apoptosis pathways (Fig. 2 22.
cFLIP regulates not only the death receptor-mediated extrinsic apoptosis pathway but also death receptor-independent apoptosis pathways.
In mammals, apoptosis pathways can be classified as either intrinsic or extrinsic6.
We demonstrate that LKB1 physically associates with p53 and regulates specific p53-dependent apoptosis pathways.
Induction of various apoptosis pathways was also observed.
In addition, DHTS also induced apoptosis in both cells through mainly mitochondrial apoptosis pathways.
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