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VEGF has been shown to be the main angiogenic factor in tumor vascularization.
Antibodies neutralising vascular endothelial growth factor (vEGF) largely blocked colony growth of the endothelial cells indicating that vEGF is the main angiogenic factor secreted by the lines.
Vascular endothelial growth factor (VEGF) has emerged as the main angiogenic factor responsible for increased vascular permeability (Rizk et al., 1997; Busso et al., 2009).
Vascular endothelial growth factor is known to be the main angiogenic factor in ovarian cancer (Yamamoto et al, 1997; Fujimoto et al, 1998; Bamberger and Perrett, 2002).
The primary targets of anti-angiogenic therapy so far have been the main angiogenic factor VEGF (vascular endothelial growth factor) or its receptor VEGFR-2 [ 2, 3].
To determine whether angiogenesis, assessed by its surrogate end point MVD, and by the expression of the main angiogenic factor VEGF, is prognostic factor in CRC, we undertook a systematic review of the literature with a meta-analysis.
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The significance of the resulting proangiogenic environment has led to the development of anti-angiogenic therapeutic agents against the main angiogenic factors.
One of the main angiogenic factors is vascular endothelial growth factor (VEGF), which exerts its function by activation of VEGF tyrosine kinase receptors [ 2].
The effects of the C-seco derivative on the expression of the two main angiogenic factors, VEGF and bFGF, were examined in GBM cells.
Here we examined whether certain agents could suppress the expression of VEGF mRNA and bFGF mRNA, which are the main angiogenic factors in RCC (Takahashi et al, 1994).
Thus, we were interested in whether genistein could suppress the expression of VEGF and bFGF, which are the main angiogenic factors in RCC.
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