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Results of our main analysis will be calculated with Cox proportional hazards models, with adjustment for five pre-specified baseline covariates.
The main analysis will follow separate analyses for alcohol and drugs.
The main analysis will be carried out on an intention-to-treat basis.
The main analysis will be conducted on the intention-to-treat (ITT) population.
The main analysis will be done using the intention-to-treat dataset.
The main analysis will compare overall survival between the two groups using unadjusted logrank test.
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Our main (primary) analysis will be a full intention-to-treat analysis on the whole trial population We will report the extent of any contamination We will undertake a sensitivity analysis using non-contaminated controls in the control arm only.
The primary analysis will consider the main treatment effects before interactions between the two treatment packages.
The primary analysis will investigate the main treatment effects of real or sham acupuncture as an adjunct to advice and exercise.
Disability due to defects arising during conception or embryogenesis will be excluded from the main analysis, but will be included in a sensitivity analysis.
Deaths from defects arising during conception or embryogenesis will be excluded from the main analysis, but will be included in a sensitivity analysis.
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